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Extra info for Advances in Parasitology, Vol. 58

Sample text

Interestingly, inhibition of activation can be induced even if the parasites are killed after phagocytosis. The phosphoglycans expressed at the cell surface are not essential for this effect to be observed, at least for the L. , 2003a, b). On the other hand, parasites are endowed with antioxidant molecules such as LPG and trypanothione (unique thiol apparently present only in the trypanosomatids) able to detoxify ROI, or molecules such as catalase and superoxide dismutase able to degrade them (Maue¨l, 1996).

Cells were then fixed and processed for peroxidase cytochemistry before embedding. HRP-containing endosomes/lysosomes (arrows) fuse with PV as indicated by the electron dense product present in the PV lumen. Presence of HRP at a parasite apex, a part of the microorganism that is involved in its attachment to the PV membrane, is also noted suggesting that this area is a centre of fusions with endocytic compartments of the host cell (arrowhead). Bar, 1 mm (micrograph from C. Fre´hel, N. -C. Antoine).

In this case, impairment of DC migration is linked to the down regulation of CCR7, a receptor for the lymphoid chemokines CCL19 and CCL21, induced by IL-10 and TNF- abundantly produced during this infection. -C. ANTOINE ET AL. L. , 2003). , 1997; Moll, 2000), as well as IFN-
-producing CD4 and CD8 T lymphocytes and IL-10-producing CD4 CD25 regulatory T lymphocytes purified from lymph nodes and/or lesions of C57BL/6 mice initially infected with a low number of L. , 2002a, 2002b). Similarly, human DCs derived from monocytes of Leishmania-infected patients and incubated with L.

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