By Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) (eds.)
ISBN-10: 0896034232
ISBN-13: 9780896034235
ISBN-10: 1475727763
ISBN-13: 9781475727760
ISBN-10: 1617370266
ISBN-13: 9781617370267
In hypersensitive reaction and Allergic ailments: the recent Mechanisms and Therapeutics, a exceptional overseas panel of researchers and clinicians evaluate the most recent findings at the mobile and molecular foundations of allergic ailments, rather these of the airway, dermis, and bowel. the major subject matters taken care of span the diversity from epidemiology and the mechanisms of irritation, to signaling in pathogenesis and allergy symptoms. each one contributor treats the pathophysiology of hypersensitivity in a number of organ-based illnesses and syndromes, emphasizing very important new findings from mobile and molecular biology that remove darkness from those ailments, but in addition show very important leads for the advance of novel medicines and healing concepts.
allergic reaction and Allergic illnesses: the hot Mechanisms and Therapeutics highlights the interface among uncomplicated and scientific technological know-how in allergic illness. Its up to date, clinically proper method constitutes the hot general wisdom base in medical immunology and allergic reaction, not just for experts, but additionally for internists, for scientists learning the mobile and molecular biology of irritation and immunity, and for researchers enthusiastic about drug discovery and therapeutics. Authoritative and well timed, hypersensitivity and Allergic ailments is obviously the state-of-the-art imperative new source for all physicians and investigators looking a deeper knowing of hypersensitivity in either its uncomplicated and medical points.
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Additional resources for Allergy and Allergic Diseases: The New Mechanisms and Therapeutics
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Rickert RC, Rajewsky K, Roes J (1995) Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352-355. 36. Stamenkovic I, Sgroi D, Aruffo A, Sy MS, Anderson T (1991) The B-Iymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T-cells and alpha 2-6 sialyltransferase, CD75, on B-cells. Cell 66:1133-1144. 37. Kapsenberg ML, Jansen HM, Bos JD, Wierenga EA (1992) Role of type 1 and type 2 T helper cells in allergic diseases.
Smerz-Bertling C, Duschl A (1995) Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J BioI Chern 270:966-970. 88. Hilton DJ, Zhang J-G, Metcalf D, Alexander WS, Nicola NA, Willson TA (1996) Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci USA 93:497-501. 89. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor.
IL-12 stimulates proliferation of activated B-, T-, and natural kellin (NK) cells, enhances lytic activity of NK cells, and synergized with IL-2 in induction of lymphokine-activated killer cells (213). Importantly, IL-12 can direct differentiation of naive T-cells into-Thl cells, secreting high levels of IFN-y. IL-12 also induces transient production of IFN-y and inhibits the production of IL-4 by already committed Th2-type allergen-specific human CD4+ T -lymphocytes (80--82). IL-12 inhibits IL-4-induced IgE synthesis by human PBMC (214).
Allergy and Allergic Diseases: The New Mechanisms and Therapeutics by Donata Vercelli MD (auth.), Judah A. Denburg MD, FRCP(C) (eds.)
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