By Edward S. Meek M D, Ch B, MRC Path (auth.)
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1961; HUMPHREY and BLANK, 1961); a response has been obtained in a number of these. , 1965), (HALL, 1966). After trying several routes of administration in ninety patients, HARRIS et ai. (1965) found an encouraging response to oral dosage in cases of malignant lymphoma and mycosis fungoides. However, a trial with cases of lung cancer proved diasppointing (MCCRACKEN and Aboody, 1965). Toxic effects include depression of bone marrow function and disturbances of the gastrointestinal tract. lg per kilo body weight if given intravenously daily for 6 days.
Toxic effects occur in marrow and gastrointestinal tract, and there is disturbance of function of the central and peripheral nervous system. The level of dosage is limited by the degree of bone marrow depression; lethal effects may result from bacterial infection following leucopenia. ARMSTRONG et al. (1967) tested vinglycinate sulphate-a modified form of vinblastine-in 31 patients with malignant disease. A useful response was recorded in cases of lung cancer, chondrosarcoma, Hodgkin's disease and lymphosarcoma.
Growth of a transplantable mouse mammary tumour has been inhibited by fractions of histone rich in lysine, and also by polylysine (SHAH and REILLY, 1967). However, other histone fractions, spermine, spermidine, protamine and puromycin had no such effects. These investigations suggest that suppression of tumour growth resulted from inhibition of the synthesis of DNA-dependent RNA. As an antiviral agent, BALANDIN et al. (1966) showed that histone extracted from calf thymus inhibits the growth of vaccinia at a concentration of 100 JLg/ml.
Antitumour and Antiviral Substances of Natural Origin by Edward S. Meek M D, Ch B, MRC Path (auth.)