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71. , AND W. OSTLUND. Susceptibility to re-addiction as a function of the addiciion and withdrawal environment. J. Comp. Physiol. Psychol. 59: 388-392, 1965. 72. , AND R. PICKENS. Drug self-administration and conditioning. In: Scientific Basis of Drug Dependence, edited by H. Steinberg. London: Churchill, 1969. 73. , AND R. PICKENS. Drugs as reinforcers: schedule considerations. 33 In: Sehedule Effects: Drugs, Drinking and Aggression, edited by R. Gilbert and J. 74. 75. 76. 77. D. Keehn, Toronto: Univ.

Rec. 22: 441-448, 1972. 14. DAVIS, W. , AND J. R. NICHOLS. A technique for self-injection of drugs in the study of reinforcement. J. Exp. Anal. Behav. 6: 233-235, 1963. 15. DAVIS, W. , AND S. G. SMITH. Alphamethyltyrosine to prevent self-administration of morphine and amphetamine. Curr. Ther. Res. 14: 814-819, 1972. 16. DAVIS, W. , AND S. G. SMITH. Blocking of morphine based rein force me nt by alpha-methyltyrosine. Life Sei. 12: 185191, 1973. 17. DAVIS, W. , AND S. G. SMITH. Haloperidol effects on morphine self-administration: testing for pharmacological modification of the primary rein forcement mechanism.

The purpose of this paper is to discuss so me of the stimulus functions of narcotic antagonists and to provide examples of situations in which these behavioral effects are modulated by pharmacological and behavioral conditions. 1 Supported by Public Health Service Grants DA 00154, DA 00254, and GM 00198. 45 James H. Woods et al. , naloxone, can elicit a number of responses. The set of responses known as the morphine abstinence syndrome includes piloerection, emesis, diarrhea, rhinorrhea, miosis, and hyperreflexia (27).

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