By Joseph Marr, Miklos Muller
The examine of parasitic organisms on the molecular point has yielded interesting new insights of serious clinical, social, and competitively priced value, and has pointed the way in which for the remedy and prevention of the ailments they reason. Biochemistry and Molecular Biology of Parasites provides an updated account of this contemporary clinical self-discipline in a fashion that permits and encourages the reader to put the biochemistry and molecular biology of those organisms of their organic context. The chapters are cross-referenced and grouped in an association that gives an absolutely built-in entire, and allows the reader to create a composite of the biochemical functionality of those organisms.
Individual bankruptcy contains these dedicated to metabolism, in either cardio and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are mentioned not just from the perspective in their mobile biochemistry and metabolism, but in addition with appreciate to either their built-in capabilities corresponding to neurochemistry, constitution and features of surfaces, and copy. Written by means of professional investigators, this publication could be of curiosity to all skilled researchers, graduate scholars, and to the newcomer desirous to familiarize yourself with the biochemistry and molecular biology of parasites.
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FEBS Lett. 62: 169-172. 6. Fairlamb, A. , Opperdoes, F. R. and Borst, P. (1976) New approach to screening drugs for activity against African trypanosomes. Nature 265: 270-271. 7. Clarkson, Jr, A. B. and Brown, F. H. (1976) Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate metabolism. Science 194: 204-206. 8. Ryley, J. F. (1962) Studies on the metabolism of protozoa. 9. Comparative metabolism of the culture and bloodstream forms of Trypanosoma rhodesiense. Biochem. J.
Mol. Biochem. Parasitol. 53: 193-200. 20. Blum, J. J. (1991) Effect of osmotic pressure on the oxidative metabolism of Leishmania major promastigotes. J. Protozool. 38: 229-233. 21. , Cannata, J. J. and Cazzulo, J. J. (1990) Carbon-13 nuclear magnetic resonance analysis of [1-13C]glucose metabolism in Trypanosoma cruzi. Evidence for the presence of two alanine pools and of two CO2 fixation reactions. Eur. J. Biochem. 192: 363-368. 30 F. R. OPPERDOES 22. Urbina, J. , Osorno, C. E. and Rojas, A. (1990) Inhibition of phosphoenol pyruvate carboxykinase from Trypanosoma (Schizotrypanum) cruzi epimastigotes by 3-mercaptopicolinic acid: in vitro and in vivo studies.
No such accumulation was observed in cells that were grown under glucose starvation. R. OPPERDOES CH2OH I c=o - I CH3 p. H3 C-OH I Glyoxylase II C=O I SG Glutathione FIG. 2 D-Lactate S-D-Lactoylglutathione The methylglyoxal pathway. Osmotic conditions influence metabolism drastically. L. major promastigotes respond to such variations by regulating their intermediary metabolism. Increased osmolality interferes with mitochondrial function, resulting in an inhibition of the oxidation of glucose, alanine, glutamate, glycerol and fatty acids (20).
Biochemistry and Molecular Biology of Parasites by Joseph Marr, Miklos Muller