Read e-book online The Glycoconjugates. Mammalian Glycoproteins and Glycolipids PDF

By Martin Horowitz

ISBN-10: 0123561019

ISBN-13: 9780123561015

The Glycoconjugates: Mammalian Glycoproteins and Glycolipids, quantity I is a collaboration of other specialists within the box of molecular biology almost about glycoconjugates.

The textual content discusses the ancient point, nomenclature, biosynthesis, and catabolism of glycoconjugates and their function in general and pathological tactics. additionally coated are themes equivalent to the purification of glycoproteins; the elucidation of the amino acid series of glycoproteins; the glycoproteins present in the several elements of the human physique; glycoenzymes; and glycohormones.

The ebook is usually recommended for molecular biologists, natural chemists, and biochemists who wish to comprehend extra approximately glycolipids and glycoproteins and their purposes.

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The presence of more than a single amino terminal amino acid in glycoproteins devoid of multiple peptide chains, as evidenced by constant composition and un­ changed molecular size of the glycoprotein following reaction with disulfidecleaving reagents, signifies the likelihood of heterogeneity. , h u m a n Zn-a 2-glycoprotein (Schmid and Burgi, 1961), admixture with one or more such glycoproteins would not be detected by this technique. The difficulty of detecting the amino terminal amino acid in a glycoprotein of very high molecular weight also diminishes the power of this method.

II. T H E C O N C E P T A N D P R O O F O F HOMOGENEITY Though the technical aspects of determining homogeneity are considered within an operational framework, from a philosophical viewpoint h o m o ­ geneity has at its roots some very fundamental problems. Homogeneity, in the sense that all of the molecules of a glycoprotein are identical in composi­ tion and molecular weight, is consistent neither with current information derived from analysis of glycoproteins nor from a consideration of their biosynthesis.

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The Glycoconjugates. Mammalian Glycoproteins and Glycolipids by Martin Horowitz

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