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By Sudhir Paul (auth.), Sudhir Paul (eds.)

ISBN-10: 0896035506

ISBN-13: 9780896035508

ISBN-10: 1461216109

ISBN-13: 9781461216100

ISBN-10: 1461272157

ISBN-13: 9781461272151

Autoimmune Reactions tackles primary questions about how the immune approach can spoil invading microbial pathogens with out inflicting harm to itself and different "self" platforms. The authoritative specialists writing right here discover the mechanistic features of such autoimmune ailments as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid ailment, and the place attainable delineate how malfunctioning immunological mechanisms can result in medical signs. in addition they speak about attainable basic mechanisms of autoimmune disease-e.g., molecular mimicry and dysfunctional antigen presentation-and their present obstacles as unifying factors of the ailments defined. furthermore, facts for novel immunological phenomena, together with antibody catalysis and the penetration of cells through antibodies, is reviewed, and their attainable organic results are pointed out. The ebook additionally seriously surveys the innovations and study that are meant to ultimately allow improvement of palliatives and treatments for autoimmune illnesses, in addition to methods to the long-standing challenge of self-nonself discrimination via the immune system.

the great, insightful evaluate supplied in Autoimmune Reactions constitutes the hot general reference for all working towards autoimmunologists, molecular immunologists, mobile and molecular pathologists, and scientific immunologists who have to stay on the state of the art of analysis on autoimmune ailment at the present time.

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Sample text

Nature 337, 562-566. 25. Goodnow, C. , and Adams, E. (1991) Breakdown of self-tolerance in anergic B lymphocytes. Nature 352, 532-536. 28 Pritsch and Dighiero 26. , Radic, M. , Camper, S. A, Hardy, R. , and Weigert, M. (1991) Expression of anti -DNA immunoglobulin trans genes in non-autoimmune mice. Nature 349,331-335. 27. , and Coutinho, A (1984) Reactions among IgM antibodies derived from normal, neonatal mice. Eur. 1. Immunol. 14,435-440. 28. , and Avrameas, S. (1985) A high incidence of cross-reactive idiotypes among murine natural autoantibodies.

In vitro studies have shown that HT-derived T-cells have a high potential for TNFa and IFNy production (110-112).

Williams, R. , Kunkel, H. , and Capra, 1. D. (1968) Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science 161,379-384. 35. , Spellerberg, M. , Hamblin, T. , Thompson, K. , et al. (1991) Nucleotide sequence analysis of the V region of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. 1. Immunol. 146, 4385-4392. 36. Silberstein, L. , Jefferies, L. , Moore, J. , Nowell, P. , et al. (1991) Variable region gene analysis of pathologic human autoantibodies to the related I and I red blood cell antigens.

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Autoimmune Reactions by Sudhir Paul (auth.), Sudhir Paul (eds.)

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