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Transplantation of fetal liver cells and thymocytes appears to be more effective than fetal liver cells alone in rodents; controlled trials in large animals and man are needed. Recent studies in dogs support that it is possible to achieve long-term survival and immune reconstitution following transplantation of a single, DLA matched fetal liver. Based on these data it may be possible to undertake comparable transplants in man. References 1. Keleman E, Calvo W, Fliedner TM: Atlas of Human Hematopoietic Development.

Vriesendorp HM, Klapwyk WM, Heidt PJ, Hogeweg B, Zurcher C, van Bekkum DW (1982) Factors controlling the engraftment of transplanted dog bone marrow cells. Tissue Antigens 20:63-80 33. Vriesendorp HM, Zurcher C (1982) Late effects of total body irradiation in dogs treated with bone marrow transplantation. In: Fliedner TM, Giissner W, Patrick G (eds) Late Effects after therapeutic whole-body Irradiation. Report EUR 8070 EN. Commission of the European Communities, Luxembourg, pp 71-88 34. Witherspoon RP, Lum LG, Storb R (1984) Immunologic reconstitution after human marrow grafting.

Non-recognizable progenitors Although the outstanding significance of different uncommitted and committed stem cells is obvious, we did not deal with this subject in this morphokinetic presentation. Nevertheless, liver cells are 2 to 5 fold enriched for these progenitors as compared with bone marrow [12]. Pluripotent haemopoietic stem cells (CFU-GEMM) in the human foetal liver were found around wk 12, about 2-3 wks before their demonstrability in the marrow [2]. Liver dyserythropoiesis monitoring intrauterine stress During the last 15 years we investigated more than 500 embryos/foetuses.

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