Get Human toxicology of chemical mixtures PDF

By Harold Zeliger

ISBN-10: 1437734634

ISBN-13: 9781437734638

In this crucial reference paintings, Zeliger catalogs the identified results of chemical mixtures

on the human physique and likewise proposes a framework for knowing and predicting their

actions when it comes to lipophile (fat soluble) / hydrophile (water soluble) interactions. The

author’s concentration is on health problems that happen following exposures to combos of chemicals

that can't be attributed to anybody portion of the mixture.

In the 1st half the mechanisms of chemical absorption at a molecular and

macromolecular point are defined, in addition to the body’s tools of protecting itself

against xenobiotic intrusion. half II examines the resources of the chemical compounds discusssed,

looking at air and water pollutants, nutrition ingredients, prescribed drugs, and so forth. half III, which

includes quite a few case reviews, examines particular results of specific combos on

particular physique structures and organs and provides a theoretical framework for predicting

what the consequences of uncharacterized combos will be. half IV covers regulatory

requirements and the necessity to alter instructed publicity degrees for products

containing combinations. It additionally includes tips on the best way to restrict publicity to

mixtures within the items we use and on the way to restrict unlock of combinations into the

environment.

Providing short summaries of every combination and its results, Zeliger presents a

comprehensive reference, a leaping off element for pros (with large chapter

bibliographies) and an advent to the subject for these learning conventional toxicology.

Addressing many inadequately understood health problems and prerequisites reminiscent of asthma,

infertility and melanoma, it's going to even be of curiosity to healthiness execs, environmental

scientists and lawyers.

  • Presents a theoretical framework for predicting the results of chemical combinations for which no particular information exists (this predictive point is critical as a result titanic variety of various strength chemical combos - a ways too many to comprehensively catalog)
  • A speedy and handy resource of tough to come back through information at the swiftly constructing box of chemical combos, for teams together with chemists and engineers, toxicologists, well-being execs and environmental scientists
  • New and up-to-date fabric contains over 30% of this well timed new version, together with the most recent learn info along an multiplied advent to the technological know-how and paintings of predicting the toxicological homes of chemical mixtures

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Extra info for Human toxicology of chemical mixtures

Example text

Potts, Penetration of industrial chemicals across the skin: a predictive model, Am. J. Ind. Med. 23 (1993) 711–719. [18] A. F. J. E. McCone, Estimating skin permeation. The validation of five mathematical skin permeation models, Chemosphere 30 (7) (1995) 1275–1296. G. Levitt, Quantitative relationship between the octanol/water partition coefficient and the diffusion limitation of the exchange between adipose and blood, Clin. Pharmacol. 10 (1) (2010). com/1472-6904/10/1.. 14 Mixture Effectsâ•… 40 Referencesâ•… 41 Human Toxicology of Chemical Mixtures.

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12 (2005) 2601–2623. [7] M. E. Appel, Carcinogenic risks of dioxin: mechanistic considerations, Regul. Toxicol. Pharmacol. 43 (1) (2005) 19–34. E. E. Kirwan, F. , Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroidmetabolizing enzymes in the liver of rat fetuses, Toxicol. Sci. 86 (2) (2005) 281–290. D. A. Roberts, Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis, Pharmacol. Toxicol. 91 (1) (2002) 1–7.

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Human toxicology of chemical mixtures by Harold Zeliger


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