Download PDF by Ronald D. Sekura: Pertussis Toxin

By Ronald D. Sekura

ISBN-10: 0126354804

ISBN-13: 9780126354805

ISBN-10: 032315848X

ISBN-13: 9780323158480

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And Ui, M. (1982) J. Biol. Chem. 257_, 7210. 10. , and Ui, M. (1982) Proc. Natl. Acad. Sei. A. 79, 3129. 11. , and Ui, M. (1983) Arch. Biochem. Biophys. 224, 290. ' 12. , and Ui, M. (1979) J. Biol. Chem. 254, 469. 13. , and Ui, M. (1981) J. Biol. Chem. 256, 8310. 14. , and Ui, M. (1981) J. Biol. Chem. 256, 2856. 15. , and Ui, M. (1981) J. Biochem. 89, 979. 16. , and Ui, M. (1982) J. Biol. Chem. 257, 3739. 17. , and Ui, M. (1983) Arch. Biochem. Biophys. 221_, 381. 18. , and Ui, M. (1983) J. Biol.

Fig. 2. Reconstitution of hemagglutination activity by mixing partially resolved pertussis toxin subunits. Chromatography of guanidine hydrochloride denatured pertussis toxin on Sephacryl S-200 (see Figure 1) results in resolution of pertussis toxin into six fractions which contain the pertussis toxin subunits as shown by SDS gel electrophoresis in the bottom of the figure. The subunits in lanes 1-6 are from top to bottom S1, S2, S3» and S4,5. Aliquots from the six fractions were mixed with an aliquot of equal volume from each of the other fraction and then assayed for hemagglutination activity with goose RBC's.

33 ISLET-ACTIVATING PROTEIN. PERTUSSIS TOXIN These activities, including lymphocytosis-promoting (Fig. 1 1 ) , histamine-sensitizing (Fig. 12) and adjuvant (Fig. 13) activities, of IAP are listed under "Class-2" in Table I. The "Class-2" activities were distinctly different from the "Class-l" activities in that much higher concentrations of IAP were required. Large amounts of the B-oligomer is probably needed for crosslinking of membrane proteins, whereas ADP-ribosylation proceeds catalytically dependent on a very few molecules of the A-protomer that have been internalized by the aid of the B-oligomer associated at the 1:1 molar ratio.

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Pertussis Toxin by Ronald D. Sekura

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