By John E. Maggio, Patrick W. Mantyh (auth.), Stephen H. Buck (eds.)
ISBN-10: 0896032663
ISBN-13: 9780896032668
ISBN-10: 1461203015
ISBN-13: 9781461203018
ISBN-10: 1461266998
ISBN-13: 9781461266990
Offers a cutting-edge assessment by means of overseas specialists on all facets of tachykinin receptors, together with neuropeptide/peptide and G-protein-linked receptors commonly. It covers the body structure, pharmacology, biochemistry, and molecular biology of those receptors from either scientific and uncomplicated study issues of view.
themes handled through the prestigious individuals comprise the characterization of tachykinin receptors, the mechanisms of tachykinin receptor motion, a mirrored image on destiny clients, and a old attention of tachykinin research.
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Lowe III, J. , Lebel, W. , Woody, H. , Drozda, S. , Desai, M. , Vinick, F. , Spencer, R. -1. (1991) A potent nonpeptide antagonist ofthe substance P (NK) receptor. Science 251, 435-437. Teichberg, V. , and Blumberg, S. (1981) Distinct classes of substance P receptors revealed by a comparison of the activities of substance P and some of its segments. Regul. Pept. 1, 327-333. , Viger, A. and Glowinski, 1. (1983) Properties of a 1251_ substance P derivative binding to synaptosomes from various brain structures and the spinal cord of the rat.
What is important is that tachykinin receptor binding should be performed in a buffer at a concentration of 20-50 mM and at physiological pH. , 1984). A similar pH optimum for PH]SP binding to chick brain membranes was reported by Too and Hanley (1988). These investigators also found that at pH 2 and 11 specific binding could no longer be detected. , 1985). , 1985). , 1980). , 1985) to study the binding of several radioligands under a variety of conditions. 4) as was also used by Hanley et aI. (1980).
Br. 1. Pharmacol. 100, 588-592. Maggi, C. , and Santicioli, P. (1991) Tachykinin receptors in the guinea-pig isolated bronchi. Eur. 1. Pharmacol. 197,167-174. Maggi, C. , and Giachetti, A. (1992) Heterogeneity ofNK-2 tachykinin receptors in hamster and rabbit smooth muscles. Regul. Pept. , and Nakanishi, S. (1987) cDNA cloning of bovine substance-K receptor through oocyte expression system. Nature 329, 836-838. Nakanishi, S. (1991) Mammalian tachykinin receptors. Annu. Rev. Neurosci. 14, 123-136.
The Tachykinin Receptors by John E. Maggio, Patrick W. Mantyh (auth.), Stephen H. Buck (eds.)
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